ATWLPPRAANLLMAAS

CAS: 1228447-26-4 F: C76H123N21O20S W: 1682.98

ATWLPPRAANLLMAAS is a chimeric peptide with anti-angiogenic and potent anti-tumor effects. ATWLPPRAANLLMAAS can inhibit

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Bioactivity	ATWLPPRAANLLMAAS is a chimeric peptide with anti-angiogenic and potent anti-tumor effects. ATWLPPRAANLLMAAS can inhibit the proliferation, viability, migration, and invasion of human hepatocellular carcinoma cells, and induce apoptosis.[1][2].
Invitro	ATWLPPRAANLLMAAS (V3) (25-200 μM; 12-24 h) 可以通过抑制 Ras/Raf/MEK/ERK 信号通路来抑制人 HCC (SMMC-7721, Huh-7) 细胞的增殖、活力、迁移和侵袭，然而，在 HL-7702 细胞中没有观察到明显的影响[2]。ATWLPPRAANLLMAAS (200 µM; 24 h) 能增加人 HCC (SMMC-7721, Huh-7) 细胞中的细胞凋亡并降低 H-RAS、磷酸化 (p)-RAF、p-MEK 和 p-细胞外信号调节蛋白激酶 (ERK) 的蛋白质水平[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> ATWLPPRAANLLMAAS 相关抗体: Cell Migration Assay [2] Cell Line:
In Vivo	ATWLPPRAANLLMAAS (160-480 μg/kg; s.c.; 一天一次连续 7 天) 可以以剂量依赖方式显著抑制小鼠移植肉瘤 S180 和 H22 肝癌移植瘤的生长[1]。ATWLPPRAANLLMAAS (200 μg/kg; s.c.; 一天一次连续 4 周) 通过下调血管生成和上调细胞凋亡来抑制人类 HCC 异种移植瘤的生长[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	1228447-26-4
Sequence	Ala-Thr-Trp-Leu-Pro-Pro-Arg-Ala-Ala-Asn-Leu-Leu-Met-Ala-Ala-Ser
Shortening	ATWLPPRAANLLMAAS
Formula	C76H123N21O20S
Molar Mass	1682.98
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Wu D, et al. Anti-tumor effects of a novel chimeric peptide on S180 and H22 xenografts bearing nude mice[J]. Peptides, 2010, 31(5): 850-864. [2]. Wu D, et al. Peptide V3 inhibits the growth of human hepatocellular carcinoma by inhibiting the Ras/Raf/MEK/ERK signaling pathway[J]. Journal of Cancer, 2019, 10(7): 1693.

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