| Bioactivity | ATV041 is an orally active Ibuprofen (HY-78131) and nucleotide analogue. ATV041 improves oral pharmacokinetic (PK) profile and tissue distribution with anti-mouse hepatitis virus (MHV) activity. ATV041 reduces viral load, tissue damage and virus-induced inflammation in a dose-dependent manner[1]. |
| Target | Mouse hepatitis virus (MHV) |
| Invitro | ATV041 抑制 CCoV、FIPV 和 TGEV，EC50 值分别为 1.406 µM、7.34 µM 和 3.777 µM[1]。 |
| In Vivo | ATV041 (200 mg/kg；口服；单剂量) 广泛且快速地分布在血浆、肝脏、肺部和肾脏组织中[1]。ATV041 (10、50 和 200 mg/kg；口服；单剂量) 以剂量依赖性方式抑制肝脏和肺中的病毒复制。ATV041 下调 TNF-α、IL-1β、IL-6、IFN-γ 和 CXCL10 炎症因子的表达，改善了组织损伤[1]。GS-441524 和布洛芬在 SD 大鼠中的药代动力学 (PK) 参数[1](GS-441524 和布洛芬由 ATV041 水解产生)Analytes |
| Name | ATV041 |
| Formula | C25H29N5O5 |
| Molar Mass | 479.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhou Q, et al. Nonsteroidal anti-inflammatory drugs (NSAIDs) and nucleotide analog GS-441524 conjugates with potent in vivo efficacy against coronaviruses. Eur J Med Chem. 2023 Jan 10;249:115113. |