| Bioactivity | ATSP-7041, a selective dual peptide inhibitor of MDM2 and MDMX, effectively reactivates the p53 tumor suppressor pathway in a mechanism-dependent manner in p53-positive cancers[1]. |
| CAS | 1451197-99-1 |
| Sequence | Ac-Leu-Thr-Phe-{R8}-Glu-Tyr-Trp-Ala-Gln-Ala-{S5}-Ser-Ala-Ala-NH2 |
| Shortening | Ac-LTF-{R8}-EYWAQA-{S5}-SAA-NH2 |
| Formula | C87H125N17O21 |
| Molar Mass | 1745.02 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yong S Chang, et al. Stapled α-helical peptide drug development: a potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):E3445-54. |
ATSP-7041
CAS: 1451197-99-1 F: C87H125N17O21 W: 1745.02
ATSP-7041, a selective dual peptide inhibitor of MDM2 and MDMX, effectively reactivates the p53 tumor suppressor pathway
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