ATR-IN-29

CAS: 2761193-67-1 F: C19H22N8O W: 378.43

ATR-IN-29 is a potent and orally active ATR kinase inhibitor with an IC50 value of 1 nM. ATR-IN-29 shows antiproliferati

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Bioactivity	ATR-IN-29 is a potent and orally active ATR kinase inhibitor with an IC50 value of 1 nM. ATR-IN-29 shows antiproliferative activity[1].
Invitro	ATR-IN-29 (compound 1) (4 days) 显示抗增殖活性，对 A549、HCC1806、HCT116、OVCAR-3、NCI-H460 细胞的 IC50 值分别为 156.70、38.81、22.48、181.60、19.02 nM[1]。
In Vivo	ATR-IN-29 (10 mg/kg；口服；一次) 在 CD-1 (ICR) 小鼠中显示出良好的药代动力学参数，t1/2 为 1.64 h，Cmax 为 9343 ng/mL，AUC0-t 为 98507 ng·h/mL，AUC0-inf 为 98517 ng·h/mL。
Name	ATR-IN-29
CAS	2761193-67-1
Formula	C19H22N8O
Molar Mass	378.43
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Sui Xiong Cai, et al. Substituted imidazo[1,5-b]pyridazine compounds as kinase inhibitors and use thereof. WO2022135560A1.