| Bioactivity | ATP (Adenosine 5'-triphosphate) magnesium is a central component of energy storage and metabolism in vivo. ATP magnesium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP magnesium is an important endogenous signaling molecule in immunity and inflammation[1][2]. |
| Invitro | ATP (5 mM；1 小时) 与 LPS (1 μg/mL) 共同处理对 HGFs 中 NLRP3 炎性体的激活具有协同作用[3]。 ATP (2 mM；0.5-24 小时) 以 caspase-1 激活依赖性方式诱导 BMDM 分泌 IL-1β、KC 和 MIP-2[4]。 ATP 促进中性粒细胞趋化性体外[4]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> ATP magnesium 相关抗体: |
| In Vivo | ATP (50 mg/kg；ip) magnesium 在体内保护小鼠免受细菌感染[4]。 ATP magnesium 在体内诱导 IL-1β、KC 和 MIP-2 的分泌以及中性粒细胞募集[4]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 1476-84-2 |
| Formula | C10H16MgN5O13P3 |
| Molar Mass | 531.49 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Swennen EL, et al. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35(3):852-8. [2]. M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404. [3]. Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514. [4]. Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8(5): e63759. |
ATP magnesium
CAS: 1476-84-2 F: C10H16MgN5O13P3 W: 531.49
ATP (Adenosine 5'-triphosphate) magnesium is a central component of energy storage and metabolism in vivo. ATP magnesium
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