Bioactivity | ATP (Standard) is the analytical standard of ATP. This product is intended for research and analytical applications. ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation.In Vitro: ATP (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs. ATP (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner. ATP promotes neutrophil chemotaxis in vitro.In Vivo: ATP (50 mg/kg; i.p.) protects mice against bacterial infection in vivo. ATP induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo. |
CAS | 56-65-5 |
Formula | C10H16N5O13P3 |
Molar Mass | 507.18 |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |