| Bioactivity | ATM Inhibitor-11 (Compound 1) is an inhibitor for ATM with an IC500 of 0.32 nM. ATM Inhibitor-11 inhibits the KAP1 phosphorylation with an IC500 of 0.97 nM. ATM Inhibitor-11 exhibits high exposure in the brain, heart and plasma of ICR mouse. ATM Inhibitor-11 exhibits anti-tumor efficacy in NCI-H441 xenograft mouse model[1]. |
| CAS | 2878473-51-7 |
| Formula | C27H33FN6O2 |
| Molar Mass | 492.59 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhao C, et al., Heterocyclic compound and preparation method and application thereof. CN115304598A. |
ATM Inhibitor-11
CAS: 2878473-51-7 F: C27H33FN6O2 W: 492.59
ATM Inhibitor-11 (Compound 1) is an inhibitor for ATM with an IC500 of 0.32 nM. ATM Inhibitor-11 inhibits the KAP1 phosp
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