| Bioactivity | ATM Inhibitor-10 (compound 74), a 3-quinoline carboxamide, is a highly selective and orally active ATM inhibitor (IC50: 0.6 nM). ATM Inhibitor-10 has anti-tumor activity in SW620 xenograft models. ATM Inhibitor-10 is synergistic with Top I inhibitors[1]. |
| Target | 0.6 nM (ATM), 370 nM (DNAPK), 1.48 μM (mTOR), 0.445 μM (PI3Kα), 12.8 μM (PI3Kβ), 7.1 μM (PI3Kγ) |
| Name | ATM Inhibitor-10 |
| CAS | 1941214-06-7 |
| Formula | C23H23FN6O2 |
| Molar Mass | 434.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Degorce SL, et al. Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase. J Med Chem. 2016 Jul 14;59(13):6281-92. |
ATM Inhibitor-10
CAS: 1941214-06-7 F: C23H23FN6O2 W: 434.47
ATM Inhibitor-10 (compound 74), a 3-quinoline carboxamide, is a highly selective and orally active ATM inhibitor (IC50:
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