ATIC-IN-1_product_DataBase

Bioactivity	ATIC-IN-1(compound 14) is an inhibitor targeting to Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization with a Ki value of 685 nM. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 exhibits anti-tumor activity via reduction in cell numbers and cell division rates[1].
Target	Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC)
Invitro	ATIC-IN-1（10 μM, 50 μM）是一种特异性抑制剂，在 1 mg/mL 和 10 mg/mL BSA 存在或不存在时，表现出非特异性聚集机制[1]。ATIC-IN-1（100-500 μM；48 h）抑制 MCF-7 细胞的增殖[1]。ATIC-IN-1（250 μM；24-72 小时）导致分裂减少而不是导致细胞死亡增加[1]。 Cell Viability Assay[1] Cell Line:
Name	ATIC-IN-1
CAS	1402453-15-9
Formula	C21H33N7O5
Molar Mass	463.53
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Spurr IB, et al. Targeting tumour proliferation with a small-molecule inhibitor of AICAR transformylase homodimerization. Chembiochem. 2012 Jul 23;13(11):1628-34.

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