| Bioactivity | ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4), which functions as a biased ligand, favoring Gαi activation over Gα13. ATI-2341 activates the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. ATI-2341 is a potent and efficacious mobilizer of bone marrow polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor cells (HSPCs)[1][2]. | ||||||
| Invitro | CXCR4[1] | ||||||
| Name | ATI-2341 TFA | ||||||
| Shortening | 1-Oxohexadecyl-MGYQKKLRSMTDKYRL | ||||||
| Formula | C106H179F3N26O27S2 | ||||||
| Molar Mass | 2370.84 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
ATI-2341 TFA
CAS: F: C106H179F3N26O27S2 W: 2370.84
ATI-2341 is a potent and functionally selective allosteric agonist of C-X-C chemokine receptor type 4 (CXCR4), which fun
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