| Bioactivity | ATF4-IN-1 (Compound 21) is an ATF4 inhibitor. ATF4-IN-1 inhibits ATF4 expression in Thapsigargin (HY-13433)-stimulatedHEK-293T cells, with an IC50 value of 32.43 nM. ATF4-IN-1 is more active than ISRIB (HY-12495A). ATF4-IN-1 exhibits low cytotoxicity (IC50: 96 μM against HEK-293T cells). ATF4-IN-1 can be used for research of neurodegenerative diseases[1]. |
| CAS | 2991057-76-0 |
| Formula | C24H21Cl2N3O4 |
| Molar Mass | 486.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Pei Y, et al. Design, Synthesis, and Biological Evaluation of Eukaryotic Initiation Factor 2B (eIF2B) Activators. ChemMedChem. 2024 Mar 1:e202300716. |
ATF4-IN-1
CAS: 2991057-76-0 F: C24H21Cl2N3O4 W: 486.35
ATF4-IN-1 (Compound 21) is an ATF4 inhibitor. ATF4-IN-1 inhibits ATF4 expression in Thapsigargin (HY-13433)-stimulatedHE
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