ATC0065_product_DataBase

Bioactivity	ATC0065 is a potent, selective and orally active melanin-concentrating hormone (MCH) receptor 1 (MCHR1) antagonist with an IC50 of 15.7 nM for human MCHR1. ATC0065 does not exhibits significant activity for MCHR2. ATC0065 has anxiolytic and antidepressant activities[1].
Invitro	ATC0065 对 5-HT2B 和 5-HT1A 受体也表现出高至中等亲和力，IC50 值分别为 266 nM 和 62.9 nM。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> ATC0065 相关抗体:
In Vivo	ATC0065（3-30 mg/kg；口服；试验前 3 小时）在大鼠中表现出抗抑郁样作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	510732-84-0
Formula	C25H31BrCl2F3N5O
Molar Mass	625.35
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Shigeyuki Chaki, et al. Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists. J Pharmacol Exp Ther. 2005 May;313(2):831-9.

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