| Bioactivity | ASP6918 is a potent and orally active KRAS G12C inhibitor with an IC50 value of 0.028 µM. ASP6918 inhibits cell growth. ASP6918 shows antitumor activity[1]. |
| Invitro | ASP6918 (compound 29a) (6 days) 抑制 NCI-H1373 细胞的细胞生长，IC50 值为 0.0061 µM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> ASP6918 相关抗体: Cell Viability Assay[1] Cell Line: |
| In Vivo | ASP6918 (10, 20, 40, 60 mg/kg; p.o.; daily for 13 days) 在 NCI-H1373 异种移植小鼠模型中显示出抗肿瘤活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C36H43N7O3 |
| Molar Mass | 621.77 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Imaizumi T, et al. Discovery of ASP6918, a KRAS G12C inhibitor: Synthesis and structure-activity relationships of 1-{2,7-diazaspiro[3.5]non-2-yl}prop-2-en-1-one derivatives as covalent inhibitors with good potency and oral activity for the treatment of solid tumors. Bioorg Med Chem. 2024 Jan 15;98:117581. |