| Bioactivity | ASO 556089 is a 16 nucleotide length gap protein (3-10-3) that targets MALAT1, a long non-coding human and mouse RNA. ASO 556089 is an antisense oligonucleotide (ASO) with the sequence 5 '-GmCATTmCTAATAGmCAGmC-3'[1]. |
| Invitro | ASO 556089 (0.16-40 µM; 72 小时) 在 2D HRPTEC 培养物中靶向 PCSK9 和 MALAT1[1]。ASO 556089 (1 和 10µM; 48 小时) 在芯片培养的 HRTEC 中引起靶转录物下调[1]。ASO 556089 (0.31-5 μM; 48 小时) 抑制 2D HRPTEC 培养物中 MALAT1 基因表达[1]。ASO 556089 (40 µM; 72 小时) 不引起细胞毒性[1]。 |
| Name | ASO 556089 |
| Molar Mass | 5414.60 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Nieskens TTG, et al. Nephrotoxic antisense oligonucleotide SPC5001 induces kidney injury biomarkers in a proximal tubule-on-a-chip. Arch Toxicol. 2021 Jun;95(6):2123-2136. |