ASM-IN-3_product_DataBase

Bioactivity	ASM-IN-3 (Compound 21b) is a selective and BBB-penetrating acid sphingomyelinase (ASM) inhibitor (IC50: 3.37 μM for pure human ASM). ASM-IN-3 improves depression-like behaviors by inhibiting ASM activity and increasing neurogenesis in hippocampus in Reserpine (HY-N0480)-induced depressed rats[1].
Invitro	ASM-IN-3 (40 μM, 0.5-4 h) 可有效穿透 hCMEC/D3 细胞膜[1]。ASM-IN-3 (0.098-12.5 μM) 对 NIH3T3 细胞是安全的 (IC50: 161 μM)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> ASM-IN-3 相关抗体:
In Vivo	ASM-IN-3 (48 mg/kg，腹腔注射) 能很好地穿透 SD 大鼠血脑屏障，因为其在脑组织中的含量远高于血浆中的含量[1]。ASM-IN-3 (6-24 mg/kg，静脉注射，每天两次，连续 2 周) 通过降低海马中 ASM 活性和恢复神经发生，在 Reserpine (HY-N0480) 诱导的抑郁大鼠中显示出良好的抗抑郁样作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	2342576-75-2
Formula	C17H13ClN2O4
Molar Mass	344.75
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Yang K, et al.. Discovery of Potent, Selective, and Direct Acid Sphingomyelinase Inhibitors with Antidepressant Activity. J Med Chem. 2020 Feb 13;63(3):961-974.

PeptideDB