| Bioactivity | ASIC-IN-1 is a potent acid sensing ion channel inhibitor with an IC50 value of < 10 µM. ASIC-IN-1 causes a dose- dependent reduction of the pain intensity[1]. |
| Target | IC50: < 10 µM (acid sensing ion channel) |
| In Vivo | ASIC-IN-1 (compound A) (50 mg/kg; i.p.) causes a dose- dependent reduction of the pain intensity as evaluated by the flinching behavior on formalin-induced spontaneous pain evoked by intraplantar injection of formalin in the rat[1]. Animal Model: |
| Name | ASIC-IN-1 |
| CAS | 308088-10-0 |
| Formula | C23H25N3O2 |
| Molar Mass | 375.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Rahul Vohra, et al. Compositions and methods for modulating gated ion channels. WO2007071055A1. |