| Bioactivity | AS115 is a potent and selective KIAA1363 inactivator with IC50 value of 150 nM. KIAA1363 is a 2-acetyl monoacylglycerol ether (MAGE) hydrolase that is upregulated in aggressive cancers of various tissues[1][2]. |
| Invitro | AS115 (10 μM, 4 h) 可显著减少 SKOV3 细胞 MAGE、烷基溶血磷脂酰胆碱和烷基溶血磷脂酸的形成[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> AS115 相关抗体: |
| CAS | 926657-43-4 |
| Formula | C21H32FNO4 |
| Molar Mass | 381.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chiang KP, et al. An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling. Chem Biol. 2006 Oct;13(10):1041-50. [2]. Jessani N, et al. Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness. Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10335-40. |