| Bioactivity | AS057278 is a potent, selective, orally active and blood-brain barrier (BBB) penetrant non-peptidic D-amino acid oxidase (DAAO) inhibitor with an IC50 value of 0.91 μM and EC50 of 2.2-3.95 μM. AS057278 can normalize phencyclidine (PCP)-induced prepulse inhibition in mice. AS057278 can be used for researching schizophrenia[1]. | ||||||||||||
| Target | IC50: 0.91 μM (DAAO) | ||||||||||||
| In Vivo | AS057278 (PO; 20 mg/kg b.i.d for 28 days; 80 mg/kg single dosage) normalizes phencyclidine (PCP)-induced prepulse inhibition[1].AS057278 (10 mg/kg; PO and IV; single dosage) exhibits good pharmacokinetic effects[1].Pharmacokinetic Parameters of AS057278 in male Sprague-Dawley rats[1]. | ||||||||||||
| Name | AS057278 | ||||||||||||
| CAS | 402-61-9 | ||||||||||||
| Formula | C5H6N2O2 | ||||||||||||
| Molar Mass | 126.11 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Adage T, et al. In vitro and in vivo pharmacological profile of AS057278, a selective d-amino acid oxidase inhibitor with potential anti-psychotic properties. Eur Neuropsychopharmacol. 2008;18(3):200-214. |