| Bioactivity | AS-254s is the inhibitor for absent, small, or homeotic-like 1 protein (ASH1L) with an IC50 of 94 nM (FP assay). AS-254s exhibits antiproliferative activity against MLL1-rearranged leukemic cells with GI50 <1 μM. AS-254s induces the differentiation of MLL1-r leukemic cell[1]. |
| Formula | C36H41ClN6O3S2 |
| Molar Mass | 705.33 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Huang G, et al., Structure-Based Development of Novel Spiro-Piperidine ASH1L Inhibitors. J Med Chem. 2025 Jan 9;68(1):174-195. |