| Bioactivity | ARN24139(compound 3f) is a topoisomerase II (topoII) inhibitor with the IC50 of 7.3 μM. ARN24139 can inhibit cancer cell proliferation and is well tolerated in vivo[1]. |
| Invitro | ARN24139(compound 3f) 具有作用于 DU145、HeLa 和 A549 细胞的抗增殖活性，其 IC50 值分别是 4.7、3.8 和 3.1μM[1]。 |
| In Vivo | The pharmacokinetic parameters of ARN24139(compound 3f) in mice Parameter |
| Name | ARN24139 |
| CAS | 2699768-78-8 |
| Formula | C24H16F3N3O4S |
| Molar Mass | 499.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jose M Arencibia, et al. Design, Synthesis, Dynamic Docking, Biochemical Characterization, and in Vivo Pharmacokinetics Studies of Novel Topoisomerase II Poisons with Promising Antiproliferative Activity. J Med Chem. 2020 Apr 9;63(7):3508-3521. |
ARN24139
CAS: 2699768-78-8 F: C24H16F3N3O4S W: 499.46
ARN24139(compound 3f) is a topoisomerase II (topoII) inhibitor with the IC50 of 7.3 μM. ARN24139 can inhibit cancer cel
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