| Bioactivity | AR/AR-V7-IN-1 (Compound 20i) is an AR/ARV7 inhibitor (IC50 = 172.85 nM). AR/AR-V7-IN-1 potently inhibits cell growth with IC50 values of 4.87 and 2.07 μM in the LNCaP and 22RV1 cell lines, respectively. AR/AR-V7-IN-1 exhibits effective tumor growth inhibition in the 22RV1 xenograft study. AR/AR-V7-IN-1 can be used for the research of prostate cancer[1]. |
| CAS | 2964558-54-9 |
| Formula | C36H43ClFN7O2 |
| Molar Mass | 660.22 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yang Y, et al. Novel selective agents for the degradation of AR/AR-V7 to treat advanced prostate cancer. Eur J Med Chem. 2024 Apr 15;271:116400. |
AR/AR-V7-IN-1
CAS: 2964558-54-9 F: C36H43ClFN7O2 W: 660.22
AR/AR-V7-IN-1 (Compound 20i) is an AR/ARV7 inhibitor (IC50 = 172.85 nM). AR/AR-V7-IN-1 potently inhibits cell growth wit
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