| Bioactivity | APJ receptor agonist 6 (compound 9) is a potent APJ (apelin receptor) agonist, with Ki of 1.3 μM. APJ receptor agonist 6 has EC50 values of 0.070 , 0.097, and 0.063 μM for calcium, cAMP, and β-arrestin, respectively[1]. |
| Target | EC50: 0.800 ± 0.1 μM (Apelin Receptor calcium), 0.844 ± 0.2 μM (Apelin Receptor cAMP), 6.22 ± 2.0 μM (Apelin Receptor β-arrestin), >10 μM (AT1 calcium) |
| Name | APJ receptor agonist 6 |
| CAS | 1965244-85-2 |
| Formula | C29H34FN3O5 |
| Molar Mass | 523.60 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Narayanan S, et al. Identification of potent pyrazole based APELIN receptor (APJ) agonists. Bioorg Med Chem. 2020 Feb 15;28(4):115237. |
APJ receptor agonist 6
CAS: 1965244-85-2 F: C29H34FN3O5 W: 523.60
APJ receptor agonist 6 (compound 9) is a potent APJ (apelin receptor) agonist, with Ki of 1.3 μM. APJ receptor agonist
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