| Bioactivity | APJ receptor agonist 4 is a potent and orally active agonist of apelin receptor (APJ) with EC50 and Ki of 0.06 nM and 0.07 nM respectively. APJ receptor agonist 4 displays excellent pharmacokinetic profiles in the rodent heart failure (HF) model. APJ receptor agonist 4 also shows an acceptable safety profile in preclinical toxicology studies. APJ receptor agonist 4 leads to improved cardiac function and can be used for researching the HF disease[1]. |
| Target | apelin receptor |
| In Vivo | Assessment of Pharmacokinetics (PK) profile of APJ receptor agonist 4 (compound 21) in mouse[1]. species |
| Name | APJ receptor agonist 4 |
| CAS | 2762567-70-2 |
| Formula | C28H28ClFN6O3 |
| Molar Mass | 551.01 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Meng W, et al. Identification of a Hydroxypyrimidinone Compound (21) as a Potent APJ Receptor Agonist for the Potential Treatment of Heart Failure. J Med Chem. 2021;64(24):18102-18113. |
APJ receptor agonist 4
CAS: 2762567-70-2 F: C28H28ClFN6O3 W: 551.01
APJ receptor agonist 4 is a potent and orally active agonist of apelin receptor (APJ) with EC50 and Ki of 0.06 nM and 0.
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.