| Bioactivity | APC 366 hydrochloride is a selective inhibitor of mast cell trypsin activity. APC 366 hydrochloride is able to inhibit trypsin-induced histamine release in human tonsil and lung cells. APC 366 hydrochloride may have important applications in regulating allergic reactions and inflammation[1]. |
| CAS | 178925-65-0 |
| Formula | C22H29ClN6O4 |
| Molar Mass | 476.96 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Barrios VE, et al. Tryptase mediates hyperresponsiveness in isolated guinea pig bronchi. Life Sci. 1998;63(26):2295-2303. [2]. Corrigendum to "Tryptase inhibitor APC 366 prevents hepatic fibrosis by inhibiting collagen synthesis induced by tryptase/protease-activated receptor 2 interactions in hepatic stellate cells" [Int. Immunopharmacol. 20 (2014) 352-357] [3]. Krishna MT, et al. Inhibition of mast cell tryptase by inhaled APC 366 attenuates allergen-induced late-phase airway obstruction in asthma. J Allergy Clin Immunol. 2001;107(6):1039-1045. |
APC 366 hydrochloride
CAS: 178925-65-0 F: C22H29ClN6O4 W: 476.96
APC 366 hydrochloride is a selective inhibitor of mast cell trypsin activity. APC 366 hydrochloride is able to inhibit t
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