| Bioactivity | AP14145 is an inhibitor for small conductance calcium-activated potassium channel, inhibits KCa2.2 channel and KCa channel with IC50 of 1.1 μM and 1.1 μM. AP14145 prolongs atrial effective refractory period (AERP) in rats, causes the conversion of atrial fibrillation to sinus rhythum in porcine left ventricular dysfunction models, and exhibits antiarrhythmic effect[1][2]. |
| CAS | 1446770-54-2 |
| Formula | C18H17F3N4O |
| Molar Mass | 362.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Citerni C, et al., Inhibition of KCa2 and Kv11.1 Channels in Pigs With Left Ventricular Dysfunction. Front Pharmacol. 2020 May 6;11:556. [2]. Simó-Vicens R, et al., A new negative allosteric modulator, AP14145, for the study of small conductance calcium-activated potassium (KCa 2) channels. Br J Pharmacol. 2017 Dec;174(23):4396-4408. |
AP14145
CAS: 1446770-54-2 F: C18H17F3N4O W: 362.35
AP14145 is an inhibitor for small conductance calcium-activated potassium channel, inhibits KCa2.2 channel and KCa chann
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