AP102_product_DataBase

Bioactivity	AP102 is a dual SSTR2/SSTR5-specific somatostatin analog (SSA). AP102 is a disulfide-bridged octapeptide SSA containing synthetic iodinated amino acids. AP102 binds with subnanomolar affinity to SSTR2 and SSTR5 (IC50: 0.63 and 0.65 nM, respectively). AP102 does not bind to SSTR1 or SSTR3. AP102 can be used for acromegaly and neuroendocrine tumors research[1].
Invitro	AP102 在体外抑制大鼠垂体前叶细胞 GHRH 刺激的 GH 释放和催乳素释放。 GH 和催乳素抑制的 IC50 水平较低（分别为 0.15 和 0.23 nM）[1]。 0 --> AP102 相关抗体:
In Vivo	AP102 (0-30 µg/kg, 皮下注射) 在健康大鼠模型中急性或慢性给药期间可急剧降低生长激素，但不会引起高血糖[1]。
Name	AP102
CAS	846569-60-6
Sequence	{4-amino-3-iodo-d-Phe}-Cys-(3-iodo-Tyr}-{d-Trp}-Lys-Val-Cys-Thr-NH2 (Disulfide bridge: Cys2-Cys7)
Shortening	{4-amino-3-iodo-d-Phe}-C-(3-iodo-Tyr}-{d-Trp}-KVCT-NH2 (Disulfide bridge: Cys2-Cys7)
Formula	C50H66I2N12O10S2
Molar Mass	1313.07
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Tarasco E, et al. Effect of AP102, a subtype 2 and 5 specific somatostatin analog, on glucose metabolism in rats. Endocrine. 2017 Oct;58(1):124-133.

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