| Bioactivity | AP-6 is a selective inhibitor of TMEM175 with activity in modulating lysosomal function. Acute inhibition of TMEM175 by AP-6 increases lysosomal macromolecular catabolism, thereby accelerating macrophage and other digestive processes. AP-6 may be used in Parkinson's disease research[1]. |
| CAS | 1369963-51-8 |
| Formula | C16H14N4 |
| Molar Mass | 262.31 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. SeCheol, et al. "Discovery of Selective Inhibitors for the Lysosomal Parkinson’s Disease Channel TMEM175." Journal of the American Chemical Society (2024). |