| Bioactivity | AP-4-139B is a heat shock protein 70 inhibitor (IC50=180 nM). HSP70 is a protein that is overexpressed in many types of cancer and is closely related to the survival and proliferation of tumor cells. AP-4-139B exhibits significant cytotoxicity to tumor cells, particularly in colorectal cancer cells. AP-4-139B can be used for cancer research[1][2]. |
| CAS | 2716909-84-9 |
| Formula | C34H33BrN3PS |
| Molar Mass | 626.59 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Barnoud T, et al. A novel inhibitor of HSP70 induces mitochondrial toxicity and immune cell recruitment in tumors[J]. Cancer research, 2020, 80(23): 5270-5281. [2]. Ferretti G D S, et al. HSP70-mediated mitochondrial dynamics and autophagy represent a novel vulnerability in pancreatic cancer[J]. Cell Death & Differentiation, 2024: 1-16. |
AP-4-139B
CAS: 2716909-84-9 F: C34H33BrN3PS W: 626.59
AP-4-139B is a heat shock protein 70 inhibitor (IC50=180 nM). HSP70 is a protein that is overexpressed in many types of
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This product is for research use only, not for human use. We do not sell to patients.