AP-1/NF-κB activation inhibitor 1_product_DataBase

CAS: 188936-12-1 F: C13H11F3N4O4 W: 344.25

AP-1/NF-κB activation inhibitor 1 is a potent AP-1 and NF-κB mediated transcriptional activation inhibitor (IC50=1 μM

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity

AP-1/NF-κB activation inhibitor 1 is a potent AP-1 and NF-κB mediated transcriptional activation inhibitor (IC50=1 μM), without blocking basal transcription driven by the β-actin promoter. AP-1/NF-κB activation inhibitor 1 has a similar inhibitory effect on the production of IL-2 and IL-8 levels in stimulated cells[1].

Name

AP-1/NF-κB activation inhibitor 1

CAS

188936-12-1

Formula

C13H11F3N4O4

Molar Mass

344.25

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Palanki MS, et al. Novel inhibitors of AP-1 and NF-kappaB mediated gene expression: structure-activity relationship studies of ethyl 4-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-2-(trifluoromethyl)++ +pyrimidi ne-5-carboxylate. Bioorg Med Chem Lett. 2000;1

PeptideDB

AP-1/NF-κB activation inhibitor 1

CAS: 188936-12-1 F: C13H11F3N4O4 W: 344.25