| Bioactivity | AOH1160 is a potent, first-in-class, orally available small molecule proliferating cell nuclear antigen (PCNA) inhibitor, interferes with DNA replication, blocks homologous recombination-mediated DNA repair, causes cell-cycle arrest and induces apoptosis. AOH1160 selectively kills many types of cancer cells (mean GI50=330 nM) without causing significant toxicity to a broad range of nonmalignant cells[1]. | ||||||||||||
| Name | AOH1160 | ||||||||||||
| CAS | 2089314-57-6 | ||||||||||||
| Formula | C25H20N2O3 | ||||||||||||
| Molar Mass | 396.44 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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