| Bioactivity | AN3199 is a PDE4 inhibitor with an IC50 of 94.5 nM. AN3199 can be used for the research of inflammation-associated diseases such as asthma and chronic obstructive pulmonary disease (COPD)[1][2]. | ||||||||||||
| Invitro | AN3199 (compound 11) (1 h) disappears (98.0%) is mainly converts to corresponding acid (76.6) in mouse plasma[1]. | ||||||||||||
| Name | AN3199 | ||||||||||||
| CAS | 1187187-10-5 | ||||||||||||
| Formula | C17H18BNO5 | ||||||||||||
| Molar Mass | 327.14 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Zhang YK, et al. Design and synthesis of boron-containing PDE4 inhibitors using soft-drug strategy for potential dermatologic anti-inflammatory application. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2270-4. [2]. Akama Tsutomu, et al. Preparation of boron-containing small molecules as anti-inflammatory agents. From PCT Int. Appl. (2009), WO 2009111676 A2 20090911. |