| Bioactivity | AMX12006 is a potent, selective and orally active EP4 antagonist with an IC50 value of 4.3 nM. AMX12006 shows cytotoxic and antitumor activity[1]. |
| Invitro | AMX12006 (0-100 µM) 具有细胞毒性，对 MCF-7、4T1、HCA-7、CT-26 WT、LLC 细胞的IC50 值分别为 46.73、79.47、>100、41.39、>100 µM[1]。 Cell Cytotoxicity Assay[1] Cell Line: |
| In Vivo | AMX12006 (75、150 mg/kg；口服；每天一次，持续 11 天) 显示出剂量依赖性的抗肿瘤活性[1]。 |
| Name | AMX12006 |
| Formula | C26H22F3N3O3 |
| Molar Mass | 481.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Debasis Das, et al. Discovery of Novel, Selective Prostaglandin EP4 Receptor Antagonists with Efficacy in Cancer Models. ACS Med. Chem. Lett. 2023. |