AMPK activator 10_product_DataBase

Bioactivity	AMPK activator 10 is an orally active, potent AMPK activator with EC150 of 44.3 nM by cell-ELISA. AMPK activator 10 increases the phosphorylation levels of ACC. AMPK activator 10 exhibits a glucose lowering effect[1].
In Vivo	AMPK activator 10 (化合物14d; 0.3, 1, 3 mg/kg; 口服灌胃; 一天2次; 21 天) 表现出降糖作用[1]。 AMPK activator 10 (0.06, 0.19, 0.56, 1.67, 5 mg/kg; 口服灌胃; 单剂量) 以剂量依赖性方式导致 ACC 的磷酸化水平升高，ACC 是 AMPK 的下游靶分子 [1]。 AMPK activator 10 (0.5 mg/kg 静脉注射或 1.0 mg/kg 口服灌胃) 在大鼠中的 CL 为 9.02 mL/min•kg，Cmax 为 65.4 ng/mL，AUC 为 347 ng •h/mL[1]。 Animal Model:
Name	AMPK activator 10
CAS	1914176-03-6
Formula	C24H26ClFN4O6
Molar Mass	520.94
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Yuusuke Tamura, et al. Identification of novel benzimidazole derivatives as highly potent AMPK activators with anti-diabetic profiles. Bioorg Med Chem Lett. 2023 Jan 1;79:129059.

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