| Bioactivity | AMG-820 is a fully human IgG2 antibody that targets CSF-1R. AMG-820 inhibits binding of the ligands CSF1 and IL34 and subsequent ligand-induced receptor activation. The isotype control for AMG-820 can refer to Human IgG2 kappa, Isotype Control (HY-P99002)[1]. |
| Invitro | AMG-820 有效抑制 CSF1 驱动的人类骨髓单核细胞增殖，以及 CSF1 和 IL34 驱动的髓单核细胞 AML-5 细胞增殖[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> AMG-820 相关抗体: |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Papadopoulos KP, et al. First-in-Human Study of AMG 820, a Monoclonal Anti-Colony-Stimulating Factor 1 Receptor Antibody, in Patients with Advanced Solid Tumors. Clin Cancer Res. 2017 Oct 1;23(19):5703-5710. |