| Bioactivity | AMG-337 is a potent, orally active, selective MET kinase inhibitor with IC50 values of 1, 1, 4.7, 5, 21.5, 1077 and >4000 nM of WT MET, H1094R MET, M1250T MET, HGF-stimulated pMET (PC3 cells) MET, V1092I MET, Y1230H MET, and D1228H MET, respectively. AMG 337 inhibits the phosphorylation of MET and downstream effectors in MET-amplified cancer cell lines, resulting in an inhibition of MET-dependent cell proliferation and induction of apoptosis[1][2]. | ||||||||||||
| Invitro | AMG 337 (0-3 µM; 72 h) inhibits proliferation in MET-dependent cancer cell lines[1].AMG 337 (0-300 nM; 0-24 h; MKN-45, SNU-620, and SNU-5 cells) inhibits signaling through the PI3K and MAPK pathways in MET-amplified gastric cancer cell lines, resulting in an inhibition of MET-dependent cell proliferation and induction of apoptosis[1]. Apoptosis Analysis[1] Cell Line: | ||||||||||||
| Name | AMG-337 | ||||||||||||
| CAS | 1173699-31-4 | ||||||||||||
| Formula | C23H22FN7O3 | ||||||||||||
| Molar Mass | 463.46 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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AMG-337
CAS: 1173699-31-4 F: C23H22FN7O3 W: 463.46
AMG-337 is a potent, orally active, selective MET kinase inhibitor with IC50 values of 1, 1, 4.7, 5, 21.5, 1077 and >400
Data collection：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.