| Bioactivity | AMG 333 is a potent and highly selective TRPM8 antagonist with an IC50 of 13 nM. | ||||||||||||
| Target | IC50: 13 nM (TRPM8) | ||||||||||||
| Name | AMG 333 | ||||||||||||
| CAS | 1416799-28-4 | ||||||||||||
| Formula | C20H12F5N3O4 | ||||||||||||
| Molar Mass | 453.32 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Horne DB, et al. Discovery of TRPM8 Antagonist ( S)-6-(((3-Fluoro-4-(trifluoromethoxy)phenyl)(3-fluoropyridin-2-yl)methyl)carbamoyl)nicotinic Acid (AMG 333), a Clinical Candidate for the Treatment of Migraine. J Med Chem. 2018 Sep 27;61(18):8186-8201. |