| Bioactivity | AMG-222 is a dipeptidyl peptidase IV (DPP-IV) inhibitor that exerts its inhibitory effect by tightly and reversibly binding to DPPIV. AMG 222 binds to human plasma proteins in a saturable and concentration-dependent manner, with a binding rate of 80.8% at 1 nM, while the binding rate decreases to 29.4% at concentrations above 100 nM. AMG-222 can be used in research related to diabetes[1]. |
| CAS | 913978-37-7 |
| Formula | C32H39N9O3 |
| Molar Mass | 597.71 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Greene R J, et al. Target-mediated metabolism and target-mediated drug disposition of the DPPIV inhibitor AMG 222[J]. Xenobiotica, 2011, 41(11): 945-957. |