| Bioactivity | AM-6494 is a potent and orally active BACE1 (efficacious β-site amyloid precursor protein cleaving enzyme 1) inhibitor (IC50=0.4 nM) with in vivo selectivity over BACE2 (IC50=18.6 nM)[1]. |
| Target | IC50: (BACE1), 18.6 nM (BACE2) |
| Name | AM-6494 |
| CAS | 1874232-80-0 |
| Formula | C22H21F2N5O3S |
| Molar Mass | 473.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Pettus LH, Discovery of AM-6494: A Potent and Orally Efficacious β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2. J Med Chem. 2019 Oct 18. |
AM-6494
CAS: 1874232-80-0 F: C22H21F2N5O3S W: 473.50
AM-6494 is a potent and orally active BACE1 (efficacious β-site amyloid precursor protein cleaving enzyme 1) inhibitor
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This product is for research use only, not for human use. We do not sell to patients.