| Bioactivity | AM-5262 is a GPR40 full agonist with an EC50 value of 0.081 μM. AM-5262 can be used for the research of type II diabetes[1]. |
| Target | EC50: 0.081 μM (GPR40) |
| Invitro | AM-5262 对 GPR40 具有活性， EC50 值为 0.081 μM[1]。 |
| In Vivo | AM-5262 (26) (i.v., 0.5 mg/kg; oral, 2 mg/kg) 改善大鼠药代动力学特征和一般选择性特征[1]。AM-5262（0-100 μM）增强葡萄糖刺激的胰岛素分泌（小鼠和人类胰岛）并改善体内葡萄糖稳态（HF/STZ 小鼠的 OGTT）[1]。 |
| Name | AM-5262 |
| CAS | 1222088-90-5 |
| Formula | C33H35FO4 |
| Molar Mass | 514.63 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wang Y, et al. Discovery and Optimization of Potent GPR40 Full Agonists Containing Tricyclic Spirocycles. ACS Med Chem Lett. 2013;4(6):551-555. Published 2013 May 7. |