ALX-5407 hydrochloride_product_DataBase

Bioactivity	ALX-5407 ((R)-NFPS) hydrochloride is a selective and orally active glycine transporter GlyT1 inhibitor with an IC50 value of 3 nM. ALX-5407 hydrochloride can be used the research of N-methyl-D-aspartate-receptor function and schizophrenia[1].
Invitro	ALX-5407 hydrochloride (0-1 mM) GlyT1- 或 GlyT2- 依赖地抑制甘氨酸转运，阻断大鼠大脑和 QT6-1C 细胞中 [3H] 甘氨酸的摄取，IC50 值为 3 nM[1]。ALX-5407 hydrochloride (50 nM) 在 QT6-1C 细胞中表现出缓慢的解离动力学[1]。
In Vivo	ALX-5407 hydrochloride (1 和 10 mg/kg；口服，一次) 增加大鼠前额叶皮层游离甘氨酸水平[1]。
Name	ALX-5407 hydrochloride
CAS	200006-08-2
Formula	C24H25ClFNO3
Molar Mass	429.91
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reference	[1]. Atkinson BN, et al. ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter. Mol Pharmacol. 2001 Dec;60(6):1414-20.

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