| Bioactivity | ALOX15-IN-2 (compound 8a) is a potent inhibitor of the linoleate oxygenase activity of rabbit and human ALOX15 with IC50s of 1.55 and 2.79 μM for ALOX15 0rthologs linoleic acid (LA) and arachidonic acid (AA), respectively[1]. | ||||||||||||
| Name | ALOX15-IN-2 | ||||||||||||
| CAS | 2764818-23-5 | ||||||||||||
| Formula | C23H29N3O4S | ||||||||||||
| Molar Mass | 443.56 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Golovanov A, et al. N-Substituted 5-(1H-Indol-2-yl)-2-methoxyanilines Are Allosteric Inhibitors of the Linoleate Oxygenase Activity of Selected Mammalian ALOX15 Orthologs: Mechanism of Action. J Med Chem. 2022;65(3):1979-1995. |
ALOX15-IN-2
CAS: 2764818-23-5 F: C23H29N3O4S W: 443.56
ALOX15-IN-2 (compound 8a) is a potent inhibitor of the linoleate oxygenase activity of rabbit and human ALOX15 with IC50
Data collection：peptidedb@qq.com
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