| Bioactivity | ALKBH1-IN-1 (Compound 13h) is a selective ALKBH1 inhibitor, with an IC50 of 0.026 μM and 1.39 μM in the fluorescence polarization and enzyme activity assay, respectively. ALKBH1-IN-1 can modulate the level of DNA 6mA modifications. ALKBH1-IN-1 can be used to study the functions of ALKBH1 and DNA 6mA[1]. |
| Invitro | ALKBH1-IN-1 (3 μM，48 小时) 可稳定过表达 ALKBH1 的 U251 细胞中的 ALKBH1 蛋白[1]。ALKBH1-IN-1 (10 μM，48 小时) 可增加 U251 细胞中 DNA 的 6mA 量[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> ALKBH1-IN-1 相关抗体: |
| Formula | C16H11F3N4O4 |
| Molar Mass | 380.28 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xiong L, et al. Discovery of a Potent and Cell-Active Inhibitor of DNA 6mA Demethylase ALKBH1. J Am Chem Soc. 2024 Mar 13;146(10):6992-7006. |