| Bioactivity | AKTide-2T is an excellent in vitro substrate for AKT and shows competitive inhibition of histone H2B phosphorylation with a Ki of 12 nM. AKTide-2T mimics the optimal phosphorylation sequence of Akt and is an inhibitory peptide with the wildtype AKTide lacking Thr in the S22 position[1]. |
| Invitro | AKTide-2T mimics the optimal phosphorylation sequence of Akt, and inhibits Akt phosphorylated Hsp27 by addition of 20 μM Akt inhibitory peptide[1]. |
| Name | AKTide-2T |
| CAS | 324029-01-8 |
| Sequence | Ala-Arg-Lys-Arg-Glu-Arg-Thr-Tyr-Ser-Phe-Gly-His-His-Ala |
| Shortening | ARKRERTYSFGHHA |
| Formula | C74H114N28O20 |
| Molar Mass | 1715.87 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. T Obata,et al. Peptide and protein library screening defines optimal substrate motifs for AKT/PKB. J Biol Chem. 2000 Nov 17;275(46):36108-15. [2]. Madhavi J Rane, et al. Heat shock protein 27 controls apoptosis by regulating Akt activation. J Biol Chem. 2003 Jul 25;278(30):27828-35. |
AKTide-2T
CAS: 324029-01-8 F: C74H114N28O20 W: 1715.87
AKTide-2T is an excellent in vitro substrate for AKT and shows competitive inhibition of histone H2B phosphorylation wit
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