| Bioactivity | Akt inhibitor-IV (AKTIV) acts as a PI3K-Akt inhibitor at the E isomer (HY-14971), with potent cytotoxicity[1]. |
| Invitro | (E)-Akt inhibitor-IV (化合物 7) 对四种细胞系 (MDA-MB468 细胞、MDA-MB231 细胞、MCF7 细胞和 184B5 细胞) 的平均 GI20 为 0.04 μM[1]。(E)-Akt inhibitor-IV 在平均 GI20 时对 184B5 非癌细胞的生长几乎没有影响[1]。 0 --> AKT inhibitor IV 相关抗体: |
| Name | AKT inhibitor IV |
| CAS | 681281-88-9 |
| Formula | C31H27IN4S |
| Molar Mass | 614.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Changkun Hu, et al. A 4-aminoquinoline derivative that markedly sensitizes tumor cell killing by Akt inhibitors with a minimum cytotoxicity to non-cancer cells. Eur J Med Chem. 2010 Feb;45(2):705-9. |