| Bioactivity | AKT-IN-17 is a AKt inhibitor. AKT-IN-17 inhibits AKt in A549 cells, leading to Apoptosis. AKT-IN-17 can be used in non-small cell lung cancer study[1]. |
| Invitro | AKT-IN-17 (176.32 μM) 对 A549 细胞具有细胞毒活性，对正常细胞 L929 无影响，IC50 为 176.32 μM[1]。AKT-IN-17 (44.06, 88.12, and 176.23 μM, 24 h) 抑制 A549 细胞内 AKt 的 IC50 为 105.88μM[1]。AKT-IN-17 (176.23 μM, 24 h) 诱导 A549 细胞早期凋亡 3.26%，晚期凋亡 1.76%[1]。 0 --> AKT-IN-17 相关抗体: Apoptosis Analysis[1] Cell Line: |
| Name | AKT-IN-17 |
| Formula | C21H21ClN4O2S |
| Molar Mass | 428.94 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Erdönmez B, et al. Design, Synthesis, and Evaluation of a New Series of Hydrazones as Small-Molecule Akt Inhibitors for NSCLC Therapy. ACS Omega. 2023 May 24;8(22):20056-20065. |