| Bioactivity | AKR1C3-IN-8 (Compound 5) is a potent, selective AKR1C3 inhibitor with an IC50 of 0.069 μM. AKR1C3-IN-8 shows antitumor activity[1]. |
| Target | IC50: 0.069 μM (AKR1C3) |
| Invitro | AKR1C3-IN-8 (Compound 5) shows antiproliferative activity with an IC50 of 52.06 ± 0.99 μM against prostate cancer cell line 22rv1[1].AKR1C3-IN-8 (0-50 μM) inhibits PSA expression and testosterone production on 22RV1 cells[1]. |
| Name | AKR1C3-IN-8 |
| Formula | C23H20N4O3 |
| Molar Mass | 400.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Pippione AC, et al. New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold. Eur J Med Chem. 2022 Jul 5;237:114366. |