| Bioactivity | AKR1C3-IN-6 (Compound 1) is a potent, selective AKR1C3 inhibitor with IC50 values of 0.31 μM and 73.23 μM against AKR1C3 and AKR1C2, respectively. AKR1C3-IN-6 shows antitumor activity[1]. |
| Target | IC50: 0.31 μM (AKR1C3), 73.23 μM (AKR1C2) |
| Invitro | AKR1C3-IN-6 (Compound 1) shows antiproliferative activity with an IC50 of 81.40 ± 2.29 μM against prostate cancer cell line 22rv1[1]. |
| Name | AKR1C3-IN-6 |
| CAS | 2137881-54-8 |
| Formula | C18H15F3N4O3 |
| Molar Mass | 392.33 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Pippione AC, et al. New aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the hydroxytriazole scaffold. Eur J Med Chem. 2022 Jul 5;237:114366. |
AKR1C3-IN-6
CAS: 2137881-54-8 F: C18H15F3N4O3 W: 392.33
AKR1C3-IN-6 (Compound 1) is a potent, selective AKR1C3 inhibitor with IC50 values of 0.31 μM and 73.23 μM against AKR1
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