| Bioactivity | AKR1C3-IN-4 is a potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC50 of 0.56 μM. AKR1C3-IN-4 has the potential for castrate resistant prostate cancer (CRPC) research[1]. |
| Target | IC50: 0.56 μM (AKR1C3) and 15.1 μM (AKR1C2) |
| Invitro | AKR1C3-IN-4 has an IC50 of 15.1 μM for AKR1C2[1]. |
| Name | AKR1C3-IN-4 |
| CAS | 1284180-11-5 |
| Formula | C14H10F3NO2 |
| Molar Mass | 281.23 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Adegoke O Adeniji, et al. Development of potent and selective inhibitors of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase) based on N-phenyl-aminobenzoates and their structure-activity relationships. J Med Chem. 2012 Mar 8;55(5):2311-23 |
AKR1C3-IN-4
CAS: 1284180-11-5 F: C14H10F3NO2 W: 281.23
AKR1C3-IN-4 is a potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC50 of 0.56 μM. AKR1C3-IN-4 h
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