| Bioactivity | AKR1C3-IN-14 (compound 4) is an AKR1C3 inhibitor (IC50=0.122 μM) that reduces the overproduction of androgens by inhibiting the activity of the AKR1C3 enzyme, thereby regulating hormone-mediated signaling. AKR1C3-IN-14 also plays a role in the biosynthesis of the prostaglandin PGF2α, regulating cell proliferation by affecting this pathway. AKR1C3-IN-14 can be used in the study of prostate cancer[1]. |
| CAS | 1057882-82-2 |
| Formula | C21H21BrN2O4 |
| Molar Mass | 445.31 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Pippione A C, et al. AI Based Discovery of a New AKR1C3 Inhibitor for Anticancer Applications[J]. ACS Medicinal Chemistry Letters, 2024. |
AKR1C3-IN-14
CAS: 1057882-82-2 F: C21H21BrN2O4 W: 445.31
AKR1C3-IN-14 (compound 4) is an AKR1C3 inhibitor (IC50=0.122 μM) that reduces the overproduction of androgens by inhibi
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