| Bioactivity | AKR1C3-IN-10 (compound 5r) is a selective AKR1C3 inhibitor (IC50=51 nM). AKR1C3-IN-10 shows good activity in a prostate cancer xenograft model[1]. |
| Target | IC50: 51 nM (AKR1C3). |
| Name | AKR1C3-IN-10 |
| Formula | C24H20N4O3 |
| Molar Mass | 412.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Maddeboina K, et al. Aldo-Keto Reductase 1C3 Inhibitor Prodrug Improves Pharmacokinetic Profile and Demonstrates In Vivo Efficacy in a Prostate Cancer Xenograft Model. J Med Chem. 2023 Jul 27;66(14):9894-9915. |